癌基因和抑癌基因.pptxVIP

癌基因和抑癌基因Measuring transformation in-vitrotransformedNormal 肿瘤是机体在各种致瘤因素的作用下,局部组织的细胞在基因水平上失掉了对其生长的正常调控,导致异常增生而形成的新生物。 致瘤因素 正常细胞 → → → 基因改变 → 肿瘤细胞Development of CancerDefective cell cycles checkpoints mechanisms allows errors in the cell duplication process to persist into the next generation and can lead to and regulated proliferation and the development of cancer、Two different types of mutations contribute to cancer formation: activating mutations in proto-oncogene and inactivating mutations in tumor suppressor genes、OncogenesStimulate ProliferationInhibit DifferentiationInhibit ApoptosisTumor