核医学教学课件：放射性核素治疗甲亢.ppt

Radionuclide Therapy The radionuclide is administered into the body and it concentrates in a certain type of supernumerary or abanormal cells. The ionising effect of radiation can destroy those cells. What is the Radionuclide Therapy? 1942Graham Bell made use of radioactive sources on tumors.This marked the beginning of curietherapy.John Lawrence injuected Phosphorus 32 to a patient as a treatment of leukaemia.Samuel Seidlin demonstrated that it was possible, following treatment with Iodine 131, to destroy thyroid cancerHistory1942Saul Hertz used Iodine 131 to treat patients affected with hyperthyroidism..1946 Radioiodine therapy for thyroid diseases Thyroid The thyroid, the largest endocrine gland in body, weighs about 20-25g. Thyroid gland secrete thyroid hormone, which enhance the growth and development of human body and energy metabloism . The iodine,in the form of iodide salt,spontaneously accumulates in the thyroid tissues. ThyroidradioiodineRadioiodine ThemeGallery is a Design Digital Content Contents mall developed by Guild Design Inc.What kinds of disesae can iodine-131 manage?Nontoxic Goiter Autonomous Functional Thyroid Nodules Graves’ dieaseDifferentiated Thyroid Carcinoma Radiodine-131 Treatment for Graves’ disease(GD) Graves diseaseGraves disease is the common cause of hyperthyroidism, representing 80%~85% of all hyperthyroidism .Graves disease is most likely an autoimmune disorder.It affects women about five times more frequntly than men. Clinlic features High metabolism symptoms heat intolerance ,weight loss,good appetite …..Diffuse goiter Palpation most frequently reveals diffuse and symmetric thyroid enlargement.Autoimmune processes mediate the enlargement of the thyroid gland.Graves’ ophthalmopathy infiltrative ophthalmopathy, tearing,a feeling of sand in the eyes, photophobia ,diplopia,and decreased visual acuity. Diffuse Goiter Graves’ ophthalmopathy antithyroid drugs Radioiodine surgery Therap