Carbobenzoxyproline-L-Cbz-Proline-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Carbobenzoxyproline Cat. No.: HY-Y0588 CAS No.: 1148-11-4 Synonyms: L-Cbz-Proline 分⼦式: C₁₃H₁₅NO₄ 分⼦量: 249.26 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 Carbobenzoxyproline (L-Cbz-Proline) 是⼀种脯肽酶 (prolidase) 抑制剂。Carbobenzoxyproline 可⽤于脯氨 酰氨基酸酶缺乏症的研究。 体外研究 Carbobenzoxyproline (6 mM; 0-10 d; pH=6.0) causes mitochondrial depolarization and increases cellular death by 33% as reported for long-term culture of fibroblasts from prolidase deficiency (PD) patients [1]. Carbobenzoxyproline (0, 1, 3, 6 mM; 1 min; pH=6.0) results fibroblasts prolidase (FBP) hydrolysis, shows linear competitive inhibition [1]. 体内研究 Carbobenzoxyproline (60 mg/kg; injection; once daily; 3 weeks) serves as in vivo inhibitor of erythrocytes prolidase in mice model [1]. Animal Model: C57Bl/6J mice (4-week-old) [1] Dosage: 60 mg/kg Administration: Injection; once daily for 3 weeks Result: Resulted significant reduction of e