Carbamazepine-d8-CBZ-d-sub-8-sub-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Carbamazepine-d8 Cat. No.: HY-B0246S2 CAS No.: 1538624-35-9 Synonyms: CBZ-d ; NSC 169864-d 8 8 分⼦式: C₁₅H₄D₈N₂O 分⼦量: 244.32 作⽤靶点: Sodium Channel; Autophagy; Mitophagy 作⽤通路: Membrane Transporter/Ion Channel; Autophagy 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Carbamazepine-d8 是氘代标记的Carbamazepine。Carbamazepine是压敏钠离⼦通道阻断剂，IC50 为 131 μM。 REFERENCES [1]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35. [2]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53. [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211- 216. McePdfHeight Caution: Product h