GnRH-Associated-Peptide-1-24-human-GAP-1-24-human-DataSheet-生命科学试剂-MCE.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE GnRH Associated Peptide (1-24), human Cat. No.: HY-P3606 CAS No.: 148943-65-1 Synonyms: GAP (1-24), human 分⼦式: C₁₁₇H₁₉₀N₃₂O₄₃ 分⼦量: 2732.95 Sequence Shortening: DAENLIDSFQEIVKEVGQLAETQR 作⽤靶点: GnRH Receptor 作⽤通路: GPCR/G Protein 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 GnRH Associated Peptide (GAP) (1-24), human 是⼈类促性腺激素释放激素相关肽 (GAP) 的 1-24 ⽚段 (hGAP- 1-24)。GAP 能够通过 3 个氨基酸加⼯位点与黄体⽣成素释放激素 (LH-RH) 序列相连。 体外研究 GAP (10 nM; 4 h) stimulates the release of both gonadotropins in anterior pituitaries from female Sprague- Dawley rats, but inhibits the basal secretion of prolactin by ~50%, compared with inhibition levels reported for dopamin, a known prolactin-inhibiting factor [2]. GAP (0.1-10 nM; 3-4 h) inhibits prolactin secretion by 40-45%, with an IC50 value of 0.25 nM [2]. REFERENCES [1]. Culler MD, et al. Development of specific antisera and a radioimmunoassay procedure for the gonadotropin-releasing hormone a