农学代谢性骨病分子细胞生物学.pptxVIP

农学代谢性骨病分子细胞生物学第1页/共49页第2页/共49页代谢性骨病代谢性骨病是一类伴有钙、磷、维生素D代谢失调以及甲状旁腺功能、细胞因子与激素分泌异常的全身性骨骼病 [代谢性骨病的分类] 1.骨质疏松 2.佝偻-软骨病 3.原发性甲状旁腺机能亢进症 4.原发性甲状旁腺机能减退症 5.中毒性骨病(维生素D、氟、镉、铅、磷等中毒) 6.其他如粘多糖代谢异常，Marfan症，Paget症, SEDT-PA。osteoporosis：Represents a continuum, in which multiple pathogenetic mechanisms converge to cause loss of bone mass and microarchitectural deterioration of skeletal structure. These factors, coupled with an increased risk of falls, contribute to a high incidence of fragility fractures in osteoporotic patients.第3页/共49页Skeletal fragility can result from: (a) failure to produce a skeleton of o