血红蛋白和免疫球蛋白.pptVIP

In sickle cell hemoglobin (HbS) glutamate in position 6 (in beta chain) is mutated to valine. This change allows the deoxygenated form of the hemoglobin to stick to each other. 第六十三页，共八十九页，2022年，8月28日 Dominant interactions between hemoglobin subunits. Hemoglobin 第三十一页，共八十九页，2022年，8月28日 A comparison of the structures of myoglobin (PDB ID 1MBO) and the subunit of hemoglobin (derived from PDB ID 1HGA). 第三十二页，共八十九页，2022年，8月28日 The looser conformation is called relaxed (松弛的) (R). The tighter conformation is called tense (紧张的) (T). The energy price for the change from the T state to the R state