脂代谢与动脉粥样硬化学习资料.pptxVIP

脂代谢与动脉粥样硬化学习资料第1页/共137页 Coronary mortality:alarming worldwide forecasts第2页/共137页 Atherosclerosis:a multifactorial disease第3页/共137页 Main risk factors for coronary heart disease第4页/共137页 Global projections for the diabetes epidemic:1995-2010第5页/共137页 Atherosclerosis第6页/共137页 Arterial wall:structure and function第7页/共137页 Different stages of atherosclerotic plaquedevelopment第8页/共137页 Vascular endothelium modificationin atherosclerosis第9页/共137页 Plaque formation1 — Fatty streak 第10页/共137页 Plaque formation2 — Fibrous cap 第11页/共137页 Plaque formation3 — Lipid core 第12页/共137页 From plaque to thrombosis, key event: plaque rupture第13页/共137页 Lipid core constitutionActivated macrophages accumulate lipids第14页/共137页 Lipid core constitutionLDL oxidation第15页/共137页 Parietal vascular inflammationThe activated macrophage produces inflammatory cytokines第16页/共137页 Parietal vascular inflammationNFkB action in the inflammation process第17页/共137页 Diabetes and atherosclerosis第18页/共137页 Tobacco and atherosclerosis第19页/共137页 Dyslipidemia and atherosclerosis第20页/共137页 HTN, hemodynamic factor and atheroclerosis第21页/共137页 How to reduce plaque formationIntervention on risk factors第22页/共137页 How to reduce the risk of plaque rupture第23页/共137页 How to reduce the risk of thrombosis第24页/共137页 ~10% Weight loss = ~30% Visceraladipose tissue loss第25页/共137页 Characteristics of an unstable plaque第26页/共137页 Plaque vulnerability factorsIntrinsic factors第27页/共137页 Modification of extrinsic vulnerability factors第28页/共137页 Plaque rupture The main releasing factors第29页/共137页 Classification of lipids and lipoproteins第30页/共137页 Characteristics of lipoproteins第31页/共137页 Triglyceride-rich lipoproteins:size, structure and composition第32页/共137页 Digestion and metabolism of dietary fat第33页/共137页 HDL metabolism and reverse cholesterol transport第34页/共137页 Cholesterol efflux and reverse cholesteroltransport is modulated by two receptors第35页/共137页 Atherogenicity of small dense LDL第36页/共137页 Size and apoli