昆虫生理学生物学 (612).pdfVIP

NIH Public Access Author Manuscript Annu Rev Entomol . Author manuscript; available in PMC 2014 June 17. N Published in final edited form as: I H Annu Rev Entomol . 2013 ; 58: 497–516. doi:10.1146/annurev-ento-120811-153608. - P A A u Ecdysone Control of Developmental Transitions: Lessons from t h o r Drosophila Research M a n 1 2 1 Naoki Yamanaka , Kim F. Rewitz , and Michael B. O’Connor u s Naoki Yamanaka: yamanaka_naoki@; Kim F. Rewitz: rewitz@ruc.dk; Michael B. O’Connor: c r moconnor@ i p 1 t Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455 2Department of Science, Systems and Models, Roskilde University, 4000 Roskilde, Denmark Abstract N The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent I H - new advances in our understanding of ecdysone action have relied heavily on the application of P A Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, A we focus on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the u t h timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to o r ecdysone, and (c) feedback regulation and coordination of ecdysone signaling. M a n u s Keywords c r i p developmental timing; metamorphosis; prothoracicotropic hormone; Ashburner model; critical t weight I