IgTCR基因重排原理及多样性.pptxVIP

IgTCR基因重排原理及多样性第1页/共26页 第2页/共26页 第3页/共26页 - The numbers of functional gene segments for the V region of human heavy and light chains ′ pseudogenes ′ : not functional protein Figure 4.3The germline organization of the Ig genes gene family Figure 4.4 第4页/共26页 第5页/共26页 第6页/共26页 Rearrangement of V,D,J gene segments - DNA rearrangements are guided by conserved noncoding DNA sequence Figure 4.5 (recombination signal sequence, RSS) ? heptamer : contiguous with the coding sequence ? spac