猪肺炎支原体的免疫时机及疫苗的选择.pptxVIP

猪肺炎支原体的免疫时机及疫苗的选择第1页/共61页 2Mycoplasma hyopneumoniae猪支原体肺炎(Mycoplasma pneumonia of swine ?MPS?)Enzootic Pneumonia (EP)第2页/共61页 3M. hyo Disease猪支原体肺炎First isolated from pig lungs in首次在猪肺脏中分离One of the most common and economically important diseases最普遍和经济意义重大的疾病之一A complex interaction between M. hyo and other bacterial and viral infections, and poor management and ventilation.主要损失是支原体和其它细菌病毒的混合感染、饲养管理不善、通风不良等综合因素所致。第3页/共61页 4M. hyo DiseaseOne of the primary pathogens causing Porcine Respiratory Disease Complex (PRDC)引起PRDC 的原发病原之一Affects as many as 99% of U.S. herds99％的美国猪群都有感染World-wide significance世界范围内养猪生产中流行第4页/共61页 5M. hyo diseaseEconomic effects are extremely variable between herds. 不同猪群的经济影响差异较大Dependent on cost of inputs, price of pigs, other diseases, etc.取决于投入的成本、猪价、其它疾病的情况等。A MOVING TARGET.第5页/共61页 6M. hyo DiseaseReduced average daily gain (ADG)降低日增重Reduced feed efficiency (FE)降低饲料报酬Increased medication costs增加药物成本Increased cull or light-weight pigs增加淘汰或低体重的猪Etc.第6页/共61页 7第7页/共61页 8M. hyo Economic LossesM. hyo decreased growth rate 12.7% and decreased feed efficiency by 13.8% (Pointon, et al,1985)肺炎支原体可降低生长率12.7%和饲料报酬13.8%第8页/共61页 9M. hyo diseaseTransmission between pigs: aerosol and direct contact猪之间传播途径：空气和直接接触Transmission between farms: movement of infected pigs 猪场之间传播方式：感染猪的移动Aerosol between farms: Britain ~3.2 km猪场之间传播距离：3.2公里第9页/共61页 10M. hyo DiseaseClinical signs include:临床症状chronic cough (often dry or nonproductive)慢性咳嗽（通常是干咳）high morbidity and low mortality高发病率和低死亡率uneven groups of pigs猪群内生长不整齐第10页/共61页 11M. hyo diseasePeak prevalence in Finisher because of:在育肥期多发的原因：Long incubation period：潜伏期长Slow spread传播缓慢Increased animal density养殖密度加大Presence of other organisms其他致病菌的出现第11页/共61页 12M. hyo PathogenesisM. hyo colonizes cilia of trachea and bronchi….paralyzing then tangling, splitting and breaking cilia….reducing normal function of mucociliary apparatus.支原体定植在气管和支气管纤毛上，导致纤毛缠绕折断、脱落，从而降低了粘液纤毛的正常功能。第12页/共61页 Only attaches to tracheobronchial