肿瘤的诱导分化和凋亡疗法.ppt

第十六章　肿瘤的诱导分化和凋亡疗法;受精卵的全能性;人体细胞总数：1014 类型：200多种 ;细胞可以通过增殖来增加数目， 那么细胞通过什么方法来改变 其结构和功能呢？;细胞分化（Differentiation);干细胞;分化异常与肿瘤干细胞;Self renewal and differentiation are random. All cells have equal but low probability of extensive proliferation. Only cells with self renewal capacity can sustain tumor growth.;Two General Models for Cancer Heterogeneity异质性;Origin of the Theory of Cancer Stem Cells;Therapeutic implications of Cancer Stem Cells;第一节 诱导分化与肿瘤治疗;Wnt, Shh, and Notch pathways have been shown to contribute to the self-renewal of stem cells and/or progenitors in a variety of org