周期性压力培养对兔骨髓间充质干细胞增殖及基质金属蛋白酶-2的影响的开题报告.docxVIP

周期性压力培养对兔骨髓间充质干细胞增殖及基质金属蛋白酶-2的影响的开题报告 摘要： 本研究旨在探讨周期性压力培养对兔骨髓间充质干细胞（BMSCs）增殖及基质金属蛋白酶-2（MMP-2）的影响。通过不同力度和频率的周期性压力刺激BMSCs，观察其增殖情况，并测定MMP-2的表达水平。结果显示，适度的周期性压力可以促进BMSCs的增殖，同时提高MMP-2的表达水平，有助于细胞迁移和组织修复。这一研究有望为骨骼肌损伤等组织修复提供新的思路和方法。 关键词：周期性压力；骨髓间充质干细胞；增殖；基质金属蛋白酶-2 Abstract: The aim of this study is to investigate the effect of cyclic pressure on the proliferation of rabbit bone marrow mesenchymal stem cells (BMSCs) and the expression level of matrix metalloproteinase-2 (MMP-2). By subjecting BMSCs to different intensities and frequencies of cyclic pressure stimulation, the cell proliferation and expression level of MMP-2 were observed. The results showed that moderate cyclic pressure can promote the proliferation of BMSCs and increase the expression level of MMP-2, which is helpful for cell migration and tissue repair. This study is expected to provide new ideas and methods for tissue repair, such as skeletal muscle injury. Keywords: cyclic pressure; bone marrow mesenchymal stem cells; proliferation; matrix metalloproteinase-2