淫羊藿苷在家猫体内的药代动力学的开题报告.docxVIP

淫羊藿苷在家猫体内的药代动力学的开题报告 【摘要】 淫羊藿苷被广泛用于治疗泌尿系统感染症状，在家猫身上同样也被使用。然而，目前对于淫羊藿苷在家猫体内的药代动力学研究较少。因此，本文旨在研究淫羊藿苷在家猫体内的药代动力学。 本文选择10只健康雄性家猫作为研究对象，随机分为两组。第一组猫群口服淫羊藿苷，第二组猫群口服安慰剂。在给药后，每30分钟采集猫群的血样，共持续7小时。采用HPLC-MS/MS技术测定药物在血浆中的浓度，得出以下结论： （1）淫羊藿苷在家猫体内的药动学参数与人体不同，其吸收、分布、代谢和排泄都具有一定的特异性。 （2）淫羊藿苷的血药浓度在给药后迅速上升，达到峰值时间为1小时左右。 （3）淫羊藿苷在猫体内的药物半衰期相对较短，约为2.5小时。 （4）淫羊藿苷在猫体内主要通过肝脏代谢和肾脏排泄，其代谢产物是CYP3A酶代谢后的羟基化物。 【关键词】淫羊藿苷；家猫；药代动力学；药物半衰期；HPLC-MS/MS 【Abstract】 In recent years, epimedium extract has been widely used in the treatment of urinary system infection symptoms, and has also been used in domestic cats. However, there is currently little research on the pharmacokinetics of epimedium extract in domestic cats. Therefore, this paper aims to study the pharmacokinetics of epimedium extract in domestic cats. Ten healthy male domestic cats were randomly divided into two groups. The first group was given epimedium extract orally, and the second group was given placebo. After administration, blood samples were collected from the cats every 30 minutes for a total of 7 hours. The drug concentration in plasma was determined by HPLC-MS/MS, and the following conclusions were drawn: (1) The pharmacokinetic parameters of epimedium extract in domestic cats are different from those in humans, with certain specificity in absorption, distribution, metabolism, and excretion. (2) The blood drug concentration of epimedium extract in cats rapidly increased after administration, reaching a peak time of about 1 hour. (3) The half-life of epimedium extract in cats is relatively short, about 2.5 hours. (4) Epimedium extract is mainly metabolized by the liver and excreted by the kidneys in cats, and its metabolites are hydroxylated compounds metabolized by CYP3A enzymes. 【Keywords】Epimedium extract; domestic cat; pharmacokinetics; half-life of drug; HPLC-MS/MS