遗传学与分子生物学系.pptx

遗传学与分子生物学系Molucular BiologyLu Shermin (吕社民)Tel:mail:lushemin@mail.xjtu.edu.cn 遗传学与分子生物学系Lecture I: Introduction Of Molecular BiologyDefinition, Goal and ScopeFundamentalsA brief historyMethodology of Molecular BiologyRole in Medical sciencesprospective 遗传学与分子生物学系DefinitionAn elusive term, More than one definition Study life (biology) in molecular level Study gene structure and function at the  molecular level. Grew out of the disciplines of genetics and biochemistry.Hybrid discipline Biochemistry Genetics Molecular Biology Biophysics  遗传学与分子生物学系GoalTo understand the five basic cell behavior patterns (growth, division, specialization, movement, and interaction) in terms of various molecules that are responsible for them 遗传学与分子生物学系ScopeStructure and function of Nucleotides and proteinStructure and function of genomeGene proliferation, expression, regulation and biological functionInteraction between biological macromolecules Intra and intermolecular signal transductionTechnology of molecular biology 遗传学与分子生物学系Scope of Medical Molecular BiologyMolecular mechanism of cellular growth, differentiation and Senescence in human beingMolecular basis of proliferation and its regulation of human cellsMolecular Biology of three regulatory systems (nervous, endocrine and immune systems) in human bodyRelationship between abnormality of gene structure, regulation with etiopathogenesis of human diseasesGene diagnosis and gene therapy in terms of theory and technology of molecular biologyDrug discovery and health care in terms of theory and technology of molecular biology 遗传学与分子生物学系Lecture I: Introduction Of Molecular BiologyDefinition, Goal and ScopeFundamentalsA brief historyMethodology of Molecular BiologyRole in Medical sciencesprospective 遗传学与分子生物学系 遗传学与分子生物学系“Weak” InteractionsChemical bonds (covalent) have energies of ~101-2 kcal/mole. STRONGWeak interactionsHydrogen bonds ~ 5 kcal/moleVan der Waals interactions ~1 kcal/mole“Hydrophobic” interac