糖皮质激素对肺炎支原体感染大鼠模型的作用研究的中期报告.docxVIP

糖皮质激素对肺炎支原体感染大鼠模型的作用研究的中期报告 摘要： 本研究旨在探讨糖皮质激素对肺炎支原体感染大鼠模型的作用。将48只健康雄性SD大鼠随机分成四组：对照组、单纯感染组、糖皮质激素组和感染+糖皮质激素组。实验初期，对单纯感染组、糖皮质激素组和感染+糖皮质激素组进行肺部CT扫描和血液生化指标检测。结果显示，单纯感染组大鼠肺部CT影像呈现受损表现，血清C-反应蛋白、白细胞计数和中性粒细胞计数均明显升高，而糖皮质激素组和感染+糖皮质激素组大鼠的肺部CT影像和血液生化指标均无明显差异。实验中期，将糖皮质激素组和感染+糖皮质激素组进行肺部组织病理学检测。结果显示，感染+糖皮质激素组大鼠肺部组织病理学损伤程度较糖皮质激素组显著降低。因此，糖皮质激素能够降低肺炎支原体感染大鼠模型的肺部损伤程度。 关键词：糖皮质激素；肺炎支原体感染；大鼠模型；肺部损伤 Abstract: The purpose of this study was to investigate the effect of glucocorticoids on the rat model of Mycoplasma pneumoniae infection. Forty-eight healthy male SD rats were randomly divided into four groups: control group, simple infection group, glucocorticoid group, and infection+glucocorticoid group. At the beginning of the experiment, lung CT scans and blood biochemical indicators were performed on the simple infection group, glucocorticoid group, and infection+glucocorticoid group. The results showed that the lung CT images of rats in the simple infection group were damaged, and the serum C-reactive protein, white blood cell count and neutrophil count were significantly increased. However, there was no significant difference in lung CT images and blood biochemical indicators between the glucocorticoid group and the infection+glucocorticoid group. In the middle of the experiment, lung tissue histopathology examination was performed on the glucocorticoid group and the infection+glucocorticoid group. The results showed that the degree of lung tissue histopathological damage in the infection+glucocorticoid group was significantly reduced compared to the glucocorticoid group. Therefore, glucocorticoids can reduce the degree of lung damage in the rat model of Mycoplasma pneumoniae infection. Keywords: Glucocorticoids; Mycoplasma pneumoniae infection; Rat model; Lung injury