s2 main生物化学与物理学学报1816.pdfVIP

Biochimica et Biophysica Acta 1840 (2014) 1808– 1816 Contents lists available at ScienceDirect Biochimica et Biophysica Acta journal homepage: A new lurium-containing amphiphilic molecule induces apoptosis in HCT116 colon cancer cells a,b,1 a,1 a,1 b a,⁎,1 Peng Du , Nathaniel Edward Be t Saidu , Johanna Intemann , Claus Jacob , Mathias Montenarh a Medical Biochemistry and Molecular Biology, University of the Saarland, Building 44, D-66424 Homburg, Germany b Bioorganic Chemistry, University of the Saarland, P.O. Box 151150, D-66123 Saarbrücken, Germany a r t i c l e i n f o Article history: Background: Chalcogen based redox modulators over the years have attracted considerable attention as anti Received 4 December 2013 cancer agents. New selenium and lurium containing compounds with a polar head group and aryl groups Received in revised form 31 January 2014 of various lengths have recently been reported as biologically active in several organisms. In the present study, Accepted 4 February 2014 we used the most active of the lurium compound DP41, and its selenium counterpart DP31 to investigate Available online 12 February 2014 their effects on the human cancer cell line HCT116. Methods: Cells were treated with