子宫颈癌组织中 CXCL12-CXCR4生物轴及 MMP2-TIMP2的表达及意义.pdf

子宫颈癌组织中 CXCL12-CXCR4 生物轴及 MMP2-TIMP2 的表达及意义 郭清;吕英璞;张玮璨;杨艳景;宋玉霞 【摘要】 目的：探讨人子宫颈癌（宫颈癌）组织 CXCL12-CXCR4 生物轴及 MMP2-TIMP2 的表达，进一步研究宫颈癌发病的过程和转移机制。方法运用免疫 组化法检测 23 例人宫颈癌患者（试验组）和因多发性子宫肌瘤行全子宫切除的患 者 25 例（对照组）宫颈组织标本中 CXCL12-CXCR4 和 MMP2-TIMP2 的表达， 研究其与子宫颈癌发病的相关性。结果与对照组相比宫颈癌组织中 CXCL12 及 CXCR4 阳性表达较多（ P 0.05 ）；与对照组相比，宫颈癌组织中 CXCL12 及 CXCR4 呈现高表达，二者与对照组比较，差异有统计学意义（ P 0.05 ）。与对 照组相比宫颈癌组织中 MMP-2 及 TIMP-2 阳性表达较多（ P 0.05 ），与对照 组相比，宫颈癌组织中 MMP-2 及 TIMP-2 呈现高表达（ P 0.05 ）。CXCL12 与 MMP2 呈正相关（ r =0.452 ，P 0.05 ）；CXCL12 与 TIMP2 呈正相关（ r =0.533 ，P 0.05 ）。结论宫颈癌发病和转移可能与 CXCL12-CXCR4 生物轴及 MMP2-TIMP2 密切相关，CXCL12 是在其中起着重要作用。%Objective To investigate the expression and significance of CXCL12-CXCR4 and MMP2- TIMP2 in cervical cancer tissues in order to explore the pathogenesis process and metastasis mechanism of cervical cancer. Methods The expression levels of CXCL12-CXCR4 and MMP2-TIMP2 were detected by immunohistochemistry in 23 patients with cervical cancer( experimental group)and 25 patients who underwent whole hysterectomy because of multiple myomata (control group). The correlation between the expressions of CXCL12-CXCR4,MMP2-TIMP2 and pathogenesis of cervical cancer was analyzed. Results As compared with those in control group,the expression levels of CXCL12-CXCR4 as well as MMP2-TIMP2 were significantly increased( P 0. 05). The expressions of CXCL12 were positively correlated to those of MMP2( r = 0. 452,P 0. 05),so were between CXCL12 and TIMP2( r = 0. 533,P 0. 05)in cervical cancer. Conclusion The pathogenesis and metastasis of cervical cancer may be closely correlated to CXCL12-CXCR4 and MMP2-TIMP2,moreover,CXCL12 may play an important role in the process. 【期刊名称】《河北医药》 【年(卷),期】2016(000)005 【总页数】3 页(P656-658) 【关键词】趋化因子;CXCL12;CXCL12-CXCR4;MMP2-TIMP2;宫颈肿瘤 【作者】郭清;吕英璞;张玮璨;杨艳景;宋玉霞 【作者单位】050011 河北省石家庄市第一医院妇产科;050011 河北省石家庄市第 一医院妇产科;050011 河北省石家庄市第一医院妇产科;050011 河北省石家庄市 第一医院妇产科;050011 河北省石家庄市第一医院妇产科 【正文语种】中 文 【中图分类】