双配体修饰壳聚糖药物载体的合成及肝靶向性能研究的中期报告.docxVIP

双配体修饰壳聚糖药物载体的合成及肝靶向性能研究的中期报告 摘要： 本研究旨在合成一种具有肝靶向性的壳聚糖药物载体，并对其进行性能评估。其中，我们采用了双配体修饰的策略，以提高该载体对肝细胞的特异性识别和细胞摄取能力。合成方法包括壳聚糖、N-甲基-D-葡萄糖胺、N-丙基乙二酰亚胺及肝细胞受体配体的反应。此外，我们还对合成产物的形貌、粒径、稳定性等进行了表征。 结果显示，所合成的双配体修饰壳聚糖药物载体具有较为均匀的球形形貌，粒径范围在100~200 nm之间，并且呈现良好的分散性和稳定性。同时，该载体对于肝细胞表现出较高的特异性识别和摄取能力，证明了双配体修饰策略的有效性。未来，我们将进一步评估该载体在体内的药物释放性能和药效学特性。 关键词： 双配体修饰；壳聚糖药物载体；肝靶向性；细胞摄取 Abstract： The aim of this study is to synthesize a liver-targeted chitosan drug carrier and evaluate its performance. In this regard, we adopted a dual ligand modification strategy to enhance the specificity recognition and cellular uptake ability of the carrier towards liver cells. The synthesis involved chitosan, N-methyl-D-glucosamine, N-propylsuccinimide, and liver cell receptor ligand. In addition, we characterized the morphology, particle size, stability, and so forth of the synthesized product. The results revealed that the dual ligand-modified chitosan drug carrier had uniform spherical morphology, with particle size ranging between 100 and 200 nm, and exhibited good dispersion and stability. Additionally, the carrier exhibited a high specificity recognition and uptake ability towards liver cells, validating the effectiveness of the dual ligand modification strategy. In the future, we will further evaluate the drug release performance and pharmacological characteristics of the carrier in vivo. Keywords： Dual ligand modification; chitosan drug carrier; liver-targeted; cellular uptake.