手性三齿Schiff-base配体及其负载化配体催化的不对称Henry反应的中期报告.docxVIP

手性三齿Schiff-base配体及其负载化配体催化的不对称Henry反应的中期报告 摘要 不对称Henry反应是一个常用的不对称碳-碳键生成方法，可用于合成具有高度手性纯度的化合物。本文报告了一种新型手性三齿Schiff-base配体及其负载化合物的制备，并对其在不对称Henry反应中的催化性能进行了研究。 研究采用简单的化学合成方法合成了两种手性三齿Schiff-base配体及其负载化合物。分别命名为L1、L2和L1-M、L2-M。对配体和负载化配体进行了结构表征，并使用NMR和HRMS对其进行了验证。 研究还对配体和负载化配体在不对称Henry反应中的催化活性进行了评估。结果表明，L1-M和L2-M具有较高的催化活性，对不对称Henry反应的产率和对映选择性均有较好的影响。 这项研究证明了手性三齿Schiff-base配体及其负载化配体在不对称Henry反应中的潜在应用，为开发更高效的手性催化剂提供了新的思路。 关键词：手性催化剂；Schiff-base配体；不对称Henry反应；负载化配体；手性纯度 Abstract Asymmetric Henry reaction is widely used to generate chiral carbon-carbon bonds and produce compounds with high enantiopurity. This paper reports the synthesis of a novel chiral tridentate Schiff-base ligand and its supported complex for use as a catalytic system in asymmetric Henry reaction. Two diastereomeric tridentate Schiff-base ligands (L1 and L2) and their supported complexes (L1-M and L2-M) were synthesized using simple chemical methods. The structures of the ligands and supported complexes were confirmed by NMR and HRMS. The catalytic activity of the ligands and supported complexes in asymmetric Henry reaction was evaluated, and it was found that L1-M and L2-M exhibited high catalytic activity, and had a good effect on both the yield and the enantioselectivity of the asymmetric Henry reaction. This study demonstrates the potential application of chiral tridentate Schiff-base ligands and their supported complexes as effective catalysts in asymmetric Henry reaction, providing a new perspective for the development of highly efficient chiral catalysts. Keywords: Chiral catalysts, Schiff-base ligand, asymmetric Henry reaction, supported complex, enantiopurity.