生理学胰岛素insulin-newversion课件.pptVIP

Insulin and Glucagon;Paul Langerhans 1869; Joseph Von Mering Oskar Minkowski 1889;;Banting, Best Diabetic dog;Delta cells (IGF);Biochemistry of Insulin;Main points:;Connections between metabolism of glucose, fatty acid and amino acid;Ⅰ Effect of Insulin on Metabolism; Protein Metabolism 1. Increase transcription of DNA, translation of mRNA; 2. Promote AA transported into cells; 3. Inhibit protein catabolism; 1-3 →protein increased 4. Depress gluconeogenesis (amino acid →glucose);Carbohydrate Metabolism ;Insulin Deficiency;Promote glycogenolysis and increa