精神科治疗药物监测的现状及发展方向.pptVIP

*浓效关系的研究浓度血清浓度、血浆浓度、全血浓度、红细胞浓度游离浓度-总浓度活性旋光异构体浓度代谢产物浓度代谢产物/原药浓度/剂量（C/Dratio）效应临床疗效副作用不良反应毒性反应受体结合率心电图脑电图*常用抗抑郁药的参考治疗浓度及警戒浓度（1）中文名英文名血浆半衰期参考治疗浓度警戒浓度阿米替林+去甲替林Amitriptyline+nortriptyline10–28h30h80–200ng/mL300ng/mL多塞平+去甲多赛平Doxepin+nordoxepin15–20h50–150ng/mL300ng/mL米帕明+地西帕明Imipramine+desipramine11–25h15–18h175–300ng/mL300ng/mL氯米帕明+去甲氯米帕明Clomipramine+norclomipramine16–60h36h230–450ng/mL450ng/mL马普替林Maprotiline20–58h75–130ng/mL220ng/mL氟西汀+去甲氟西汀Fluoxetine+norfluoxetine4–6days4–16da