新型冠状病毒感染脆弱人群的识别及防治展望.pdfVIP

新型冠状病毒感染脆弱人群的识别及防治展望

【摘要】新型冠状病毒感染疫情对人类健康和全球经济造成重创。健康相关脆弱人群的免疫功能减退，导致疫

苗的防护效果不足，并且，感染新型冠状病毒后重症和死亡风险更高，而目前尚缺乏足够有针对性的新型冠状病毒感

染预防和治疗药物。在我国“乙类乙管”的防疫背景下，脆弱人群成为疫情防控的重点人群。因此，针对脆弱人群应

该进一步优化个体免疫和防控策略，在疫苗之外，还需要补充其他预防手段，如长效中和抗体。基于此，本文将对脆

弱人群的识别、免疫功能特点与预防方法进行综述，为国内健康相关脆弱人群的防治策略提供参考，期待未来可以研

发出更适宜脆弱人群的预防药物，降低脆弱人群感染新型冠状病毒的风险。

【关键词】新型冠状病毒感染；脆弱人群；长效中和抗体；预防；综述

IdentificationofCOVID-19InfectioninVulnerablePopulationandItsPreventionandTreatment

Perspectives

【Abstract】TheCOVID-19pandemichasdevastatedhumanhealthandglobaleconomy.Diminishedimmunefunction

ofhealth-relatedvulnerablepopulationsleadstoinsufficientprotectiveeffectofthevaccinewithahigherriskofsevereillnessand

deathfollowinginfection，andthereisalackofadequatetargeteddrugsforthepreventionandtreatmentofCOVID-19.Inthe

contextthatCOVID-19treatedasaCategoryBdiseaseinChina，vulnerablepopulationshavebecometheprioritypopulations

forepidemicpreventionandcontrol.Therefore，thestrategiesofindividualimmunizationandpreventionshouldbefurther

optimizedforvulnerablepopulations.Inadditiontovaccines，otherpreventionstrategiesshouldbesupplemented，suchas

long-actingneutralizingantibodies.Basedonthis，thispaperreviewstheidentification，immunefunctioncharacteristicsand

preventionstrategiesofCOVID-19invulnerablepopulations，toprovideareferenceforthepreventionandcontrolstrategiesfor

health-relatedvulnerablepopulationsinChina，expectingthatmoresuitablepreventivedrugsforvulnerablepopulationscanbe

developedinthefuturetoreducetheriskofCOVID-19invulnerablepopulations.

【Keywords】COVID-19；Vulnerablepopulations；Long-actingneutralizingantibody；Prevention；Review

世界卫生组织2020年3月宣布新型冠状病毒感染表1新型冠状病毒感染相关健康风险评分表

Table1COVID-19infection-relatedhealthriskscorescale

（以下简称新冠）大流行，截至