抗肿瘤物质筛选模型的建立及其应用的综述报告.docxVIP

抗肿瘤物质筛选模型的建立及其应用的综述报告

Abstract：

Cancerisamajorthreattohumanhealth.Thedevelopmentofanti-tumorsubstanceshasalwaysbeenoneofthehotspotsinthefieldofpharmaceuticalresearch.Inordertodiscovermoreeffectiveandspecificanti-tumordrugs,itisnecessarytoestablishareliablemodelforscreeninganti-tumorsubstances.Inthisarticle,wewillreviewtheestablishmentandapplicationofavarietyofanti-tumorsubstancescreeningmodels,includinginvitro,invivo,andcomputationalsimulations.Thesemodelshavemadegreatcontributionstothediscoveryanddevelopmentofanti-tumordrugs.

Keywords:anti-tumorsubstances,screeningmodel,invitro,invivo,computationalsimulation

Introduction：

Cancerhasbecomeoneofthemajorthreatstohumanhealth.Althoughsignificantprogresshasbeenmadeinthediagnosisandtreatmentofcancerinrecentyears,thereisstillalongwaytogotodiscovertrulyeffectiveandtargetedanti-tumoragents.Thedevelopmentofanti-tumordrugsrequiresareliablescreeningmodeltoidentifypotentialcompounds.

Theestablishmentofascreeningmodelforanti-tumorsubstancesisofgreatsignificancetothediscoveryofeffectivedrugs.Invitro,invivo,andcomputationalsimulationmethodshavebeenwidelyusedtoestablishdifferentanti-tumorsubstancescreeningmodels.Eachmodelhasitsownadvantagesandlimitations.

Invitroscreeningmodels：

Invitroscreeningmodelsrefertotheuseofcellculturesystemstoevaluatethetoxicityandeffectivenessofanti-tumoragents.Avarietyofcelllineshavebeenusedtoestablishinvitroscreeningmodels,suchashumantumorcelllinesandanimalcelllines.Thesemodelsallowfortheassessmentofcellproliferation,cellcycle,apoptosis,andotherimportantparameterstodeterminethepotentialeffectivenessofdrugs.

Oneexampleofaninvitroscreeningmodelisthehigh-throughputscreening(HTS)method.Thismethodcanscreenhundredsofthousandsof