江泽飞：精准指导 全程管理.pdf

江泽飞

•Theinitiativewillencourageandsupportthenext

generationofscientiststodevelopcreativenew

approachesfordetecting,measuring,andanalyzinga

widerangeofbiomedicalinformation—including

molecular,genomic,cellular,clinical,behavioral,

physiological,andenvironmentalparameters.

群体分类

全程管理

最佳维持

联合治疗

NP/GPNX/TX–X

TAMPost-AI

AI

HER2标准建立HER2耐药探究新靶点不断出现

FabriceAndreat2014ASCOAnnualMeeting

NEJM2001

H+T

9

10

液体肿瘤标志物动态监测

CTC读书看病科学算命

l

a

v

i

v

r100

uGroupDescriptionN(%)Median

S

901Baseline5136(61%)39.0

e

e802Baseline≥5,3-4weeks5CTC50(22%)26.6

r3Baseline≥5,3-4weeks≥5CTC38(17%)7.3

F

n70

o

i

s60

s

e

r50

g

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r40Logrank

P

f30p0.0004

o

y

t20

i

l

i

b10

a

b0

o

r051015202530354045505560

P

%

TimefromfirstFollow-upVS.Baseline(Weeks)

MBC第一次随访期与基线期对比CTC变化

对PFS具有预测价值

ZFJiangetal.AnnalsofOncology7,2013

解救治疗抗HER2治疗

HER2阳性解救治疗前