先天性感音聋幼儿的内耳形态学研究及听觉传导通路的DTI评估的开题报告.docxVIP

先天性感音聋幼儿的内耳形态学研究及听觉传导通路的DTI评估的开题报告

【摘要】

背景：先天性感音聋是全球公共卫生问题之一，但其病因及发病机制仍不完全清楚。内耳结构及听觉传导通路异常是常见原因之一。

目的：本研究旨在探讨先天性感音聋幼儿内耳形态学变化及听觉传导通路的DTI评估结果，为该病的早期诊断及治疗提供依据。

方法：纳入20例先天性感音聋幼儿及20例正常对照幼儿，采用高分辨CT扫描及DTI技术进行内耳形态学及听觉传导通路评估。比较两组幼儿内耳结构差异并分析其相关性。

结果：先天性感音聋幼儿与正常对照幼儿相比，其内耳结构存在明显异常：包括内淋巴腔积液、前庭及半规管发育异常等。DTI评估结果显示，先天性感音聋幼儿听觉传导通路存在明显异常，白质纤维束的FA值显著降低。

结论：先天性感音聋幼儿内耳结构及听觉传导通路存在异常，可能导致听觉传导受阻甚至耳蜗萎缩。本研究结果可为该病的早期诊断及治疗提供重要依据。

【关键词】先天性感音聋；内耳结构；听觉传导通路；DTI

【Abstract】

Background:Congenitalsensorineuralhearinglossisaglobalpublichealthissue,butitsetiologyandpathogenesisarenotfullyunderstood.Abnormalitiesininnerearstructureandauditorypathwaysarecommoncauses.

Objective:ThisstudyaimstoinvestigatethechangesininnerearmorphologyandtheDTIevaluationresultsofauditoryconductionpathwaysincongenitalsensorineuralhearinglossinfants,andprovideabasisforearlydiagnosisandtreatmentofthedisease.

Methods:Atotalof20infantswithcongenitalsensorineuralhearinglossand20normalcontrolinfantswereincluded,andhigh-resolutionCTscanningandDTItechnologywereusedforinnerearmorphologyandauditoryconductionpathwayevaluation.Differencesintheinnerearstructurebetweenthetwogroupsofinfantswerecomparedandanalyzed.

Results:Comparedwithnormalcontrolinfants,infantswithcongenitalsensorineuralhearinglosshadobviousabnormalitiesininnerearmorphology,includingendolymphatichydrops,abnormaldevelopmentofthevestibuleandsemicircularcanals,etc.TheDTIevaluationresultsshowedthatthereweresignificantabnormalitiesintheauditoryconductionpathwaysofinfantswithcongenitalsensorineuralhearingloss,andtheFAvalueofwhitematterfiberswassignificantlydecreased.

Conclusion:Infantswithcongenitalsensorineuralhearinglosshaveabnormalitiesininnerearstructureandauditoryconductionpathways,whichmaycauseobstructionofauditoryconductionandevenatrophyofthecochlea.Theresultsof