EGFRIs皮肤毒性的发生机制和处理策略.pptVIP

*爱必妥联合放疗在头颈部鳞癌*西妥昔单抗联合FOLFIRI方案一线治疗晚期结直肠癌*Theresponseratesinpatientswhodevelopedsignsofskinreactionswerehigherthaninpatientswithoutskintoxicity(25.8%vs.6.3%forthecombinationarmand12.9%vs.0%forthemonotherapyarmrespectively).Themediansurvivalforpatientswithandwithoutskintoxiciteswere9.1monthsvs.3.0monthsrespectivelyinthecombinationarmand8.1monthsvs.2.5monthsrespectivelyforthemonotherapyarm.Acne-likeormaculopapularrashisconsideredacharacteristicsideeffectfortheclassofEGFRblockadeduetotheimportantroleo