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Animation动画:ShigellaPassingThroughtheMucousMembrane
andInvadingMucosalEpithelialCells黏膜上皮细胞Pathogenesisoftoxicdysentery中毒性痢疾Overall,themechanismisnotclear.Itmayberelativetosuper-allergyreactioncausedbyendotoxin,particularlyinchildrenwithspecialimmunity.Toxicencephalopathy脑病isresponsiblefordeathofchildren5.ClinicalmanifestationIncubationperiod潜伏期:1to2days(upto7days)Duration(courseofdisease):4daysto2weeksClinicaltypeMildtypeTypicaltype(moderate)Toxictype(severe)2.Chronic1.AcuteClinicaltypeTypicaltypeSymptoms:SuddenlyonsetWholebodytoxemia:chill,fever,fatigue,,headache…Crampingabdominalpain,especiallyinleftinferiorabdomenDiarrhea:waterstoolinitially,thenbloodypurulentstools,10~20timesperday.BurningsensationatAnus---tenesmus,duetonervesofrectum直肠beingstimulatedbylocalinflammation,asymptomcharacterizedbyincompletesenseofevacuation排泄withrectal直肠的(anus)painSigns:Press-painontheleftinferiorabdomen(appendicitis阑尾炎:ontheright!)ClinicaltypeMildtypeMildtoxemia,nosignificantfeversometimesWithouttypicalbloodypurulentstools,thefrequencyofthestoolsislessthan10timesperday.Mostcasescanrecovercompletelyandtherestmaybedevelopedintochronic.ClinicaltypeToxictypeUsuallyfoundinhealthychildrenwith2~7yearsold.Onsetsuddenlywithfever(400C)andserioustoxemiaToxinencephalopathy中毒性脑病Mentaldisorder:lethargy昏睡,coma昏迷andconstrictions颈缩.Toxinencephalopathyrespiratoryfailure.Infectiousshock:BPdecrease,skinbecomecold,multiorganfailureinvolvesthekidney,lungs,andliver;DIC(disseminatedintravascularcoagulation)andheartfailuremayalsooccur.usuallyWithoutdiarrheaorabdominalpainClinicaltypeChronictypeHavingapasthistoryofacutebacillarydysenteryHavi
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