维生素D相关文献Targeted 25-hydroxyvitamin D concentration measurements and vitamin D3 supplementation can have important patient and public health benefits.pdf

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EuropeanJournalofClinicalNutrition

/10.1038/s41430-020-0564-0

REVIEWARTICLE

Targeted25-hydroxyvitaminDconcentrationmeasurementsand

vitaminD3supplementationcanhaveimportantpatientandpublic

healthbeneﬁts

123

WilliamB.Grant●FatmeAlAnouti●MeisMoukayed

Received:2October2019/Revised:8January2020/Accepted:15January2020

©TheAuthor(s),underexclusivelicencetoSpringerNatureLimited2020

Abstract

Overthepasttwodecades,manystudiesreportedthebeneﬁtsofhigher25-hydroxyvitaminD[25(OH)D]concentrationsfor

nonskeletaleffects.Researchersfoundsigniﬁcantbeneﬁtsinreducingriskofacuterespiratorytractinfections,manytypesof

cancer,type2diabetesmellitus,prematuredeath,andadversepregnancyandbirthoutcomes.Inaddition,25(OH)D

:concentrationsarelowforvariousreasonsinseveralcategoriesofpeople,includingtheobese,thosewithdarkskinlivingat

(;

)

90higherlatitudes,theelderly,andthosewhodonoteatmucheggs,ﬁsh,meat,orvitaminDfortiﬁedmilk.Measuring25(OH)

55DconcentrationsisonewaytobothincreasetheawarenessofvitaminD’simportanceinmaintaininggoodhealthandto

11encouragevitaminDsupplementationorincreasedsolarultraviolet-Bexposuretosustainwell-beingthroughoutlifeby

reducingdiseaseincidence.Although20ng/mlseemsadequatetoreduceriskofskeletalproblemsandacuterespiratorytract

infections,concentrationsabove30ng/mlhavebeenassociatedwithreducedriskofcanc

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