维生素D相关文献Share Assessing a method and reference material for quantification of vitamin D binding protein during pregnancy..pdf

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维生素D相关文献Share Assessing a method and reference material for quantification of vitamin D binding protein during pregnancy..pdf

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ClinicalMassSpectrometry16(2020)11–17

ContentslistsavailableatScienceDirect

ClinicalMassSpectrometry

journalhomepage:www.else/locate/clinms

Assessingamethodandreferencematerialforquantiﬁcationofvitamin

Dbindingproteinduringpregnancy

LisaE.Kilpatricka,⇑,AshleyS.P.Boggsb,W.ClayDavisb,StephenE.Longb,JamesH.Yena,

KarenW.Phinneya

aNationalInstituteofStandardsandTechnology,MaterialMeasurementLaboratory,BiomolecularMeasurementDivision,100BureauDrive,Gaithersburg,MD20899,UnitedStates

bNationalInstituteofStandardsandTechnology,ChemicalSciencesDivision,HollingsMarineLaboratory,331FortJohnsonRoad,Charleston,SC29412,UnitedStates

articleinfoabstract

Articlehistory:VitaminDplaysavitalroleinsuccessfulpregnancyoutcomesforboththemotherandfetus.VitaminDis

Received6November2019boundtovitaminDbindingprotein(VDBP)inbloodandiscarriedtotheliver,kidneysandothertarget

Receivedinrevisedform7January2020tissues.AccuratemeasurementsoftheclinicallymeasuredmetaboliteofvitaminD,25-hydroxyvitaminD

Accepted20January2020

[25(OH)D],dependoncompleteremovalfromthebindingprotein.IthasbeenfoundthatVDBPconcen-

Availableonline23January2020

trationsincreaseinmaternalserumduringpregnancy,obfuscatingtheaccuracyof25(OH)Dconcentra-

tionmeasurementsinpregnantwomen.Additional

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维生素D相关文献Share Assessing a method and reference material for quantification of vitamin D binding protein during pregnancy..pdf