信必可都保装置 PPT课件.ppt

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2024-07-07 发布于浙江
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信必可都保装置 PPT课件.ppt

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*Wehaveinforamtionthatshowsthatwecanusetheinvitroinformationthatwegenerateinthelaboratorytopredicttheinvivolungdepositionoutcome.Wehavealsoinformatinthatcorrelatestheinvivolungdepositiondatawiththeclinicalaffect.Tellingusthattheamontofdrugreeachingthelungsisifimprtanceforthelelicitedeffect.uprisingpartofthedoserepsonsecurvewecanpredictfrominvitrotoinvivo.

**Sufficientpeakinspiratoryflow(PIF)canbegeneratedinyoungchildrentoensureclinicalbenefit.St?hletal(1996)Youngchildenaged3-10yearscouldproducethepeakinspiratoryflowratesthroughTurbuhaler?neededforadequateuseofthedevice.Childrenaged3-6yearsachievedameanPIFof60L/min.Meanageofthe38patientsin3-6yearoldgroupwas5.5yearsinPortugaland5.2yearsinSweden.Atotalof6childrenwerebelowtheageof5.Correspondingmeanforchildrenaged7-10yearswas70L/minInthisgroupofchildren,inhalationofterbutalineviaTurbuhaler?gavegoodbronchodilationandfewadverseeventsirrespectiveofdose(0.25,0.5and1mg)TherecommendedageforuseofTurbuhalerinchildrenisfrom5yearsold.AgertoftandPedersen(1998)demonstratedwithindividualinstructionsandhometraining,thevastmajorityofchildrenaged4and5yearscanuseTurbuhalercorrectly.However,few3yearoldchildrencanlearnthecorrectuseofTurbuhaler.Thus,theinabilityforsmallchildrentouseTurbuhalerisduetocognitiveeffects.St?hlE,RibeiroLB,SandahlG(1996)DoseresponsetoinhaledterbutalinepowderandpeakinspiratoryflowthroughTurbuhaler?inchildrenwithmildtomoderateasthma.PediatrPulmonol22:106.110.*Thestudycomprised100patients(45men,55women,meanage69.1years)withCOPD(meanduration17.7(16.3)years).Aseriesofrandomlyassignedinspiratoryandexpiratorylungfunctiontestswerecontinuouslyperformed,usingportablespirometers,within48hofa