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新型抗生素的研发进展
DevelopmentofNovelAntibiotics:ProgressandChallenges
新型抗生素的研制:进展与挑战
Abstract
Withtheincreasingprevalenceofmulti-drugresistant(MDR)
bacteria,thedevelopmentofnovelantibioticshasbecomean
urgentpublichealthpriority.Thispapersummarizesthecurrent
statusofnovelantibioticdevelopment,includingtheidentification
ofnewtargets,thediscoveryofnaturalandsyntheticcompounds,
andtheapplicationofinnovativetechnologies.Despitesome
encouragingprogress,therearestillnumerouschallengesahead,
suchasclinicalvalidation,regulatoryapproval,andequitable
access.Nonetheless,thedevelopmentofnovelantibioticsholds
greatpromisefortacklingtheglobalthreatofMDRbacteria.
Keywords:antibiotics,drugdiscovery,multi-drugresistance
摘要
随着多重耐药菌的日益普及,新型抗生素的研发已成为迫切的
公共卫生问题。本文总结了新型抗生素研发的当前情况,包括
发现新的靶标、发现天然合成化合物以及应用创新技术。尽管
已经取得了一些有益的进展,但仍然存在许多挑战,例如临床
验证、监管批准和平等获得权等。然而,开发新型抗生素对于
解决多重耐药性细菌的全球威胁充满希望。
关键词:抗生素、药物发现、多重耐药
Introduction
Sincethediscoveryofpenicillinin1928,antibioticshave
revolutionizedthepracticeofmedicineandsavedcountlesslives.
However,theoveruseandmisuseofantibioticshaveledtothe
emergenceandspreadofmultidrug-resistant(MDR)bacteria,
whichposeaseriousthreattoglobalhealth.Accordingtothe
WorldHealthOrganization(WHO),antibioticresistanceisoneof
thetoptenglobalpublichealththreatsfacinghumanity.Inrecent
years,therehasbeenagrowingrecognitionoftheurgentneedfor
thedevelopmentofnovelantibioticstocombatMDRbacteria.
IdentificationofNewTargets
Thetraditionalapproachtodrugdiscoveryhasreliedonscreening
chemicallibrariesforcompoundsthatcaninhibitthegrowthor
replicationofbacteria.However,thismethodhasencountered
diminishingreturns,asmanypotentialdrugtargetshavealready
beenexploited,andtheeffectivenessofexistingantibioticshas
decreasedduetores
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