英文论文投稿信Cover letter 模板.pdf

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英文论文投稿信Cover?letter模板

qiusuoBY-2006-1-178:59:00

DearEditor,

tobeconsideredforpublicationinNatureNeuroscience.

GDNFhaslongbeenthoughttobeapotentneurotrophicfactorforthesurvivalofmidbrain

dopaminergicneurons,whicharedegeneratedinParkinson’sdisease.Inthispaper,wereportan

unexpected,acuteeffectofGDNFonA-typepotassiumchannels,leadingtoapotentiationof

neuronalexcitability,inthedopaminergicneuronsincultureaswellasinadultbrainslices.

Further,weshowthatGDNFregulatestheK+channelsthroughamechanismthatinvolves

activationofMAPkinase.Thus,thisstudyhasrevealed,forthefirsttime,anacutemodulationof

ionchannelsbyGDNF.OurfindingschallengetheclassicviewofGDNFasalong-termsurvival

factorformidbraindopaminergicneurons,andsuggestthatthenormalfunctionofGDNFisto

regulateneuronalexcitability,andconsequentlydopaminerelease.Theseresultsmayalsohave

implicationsinthetreatmentofParkinson’sdisease.

Duetoadirectcompetitionandconflictofinterest,werequestthatDrs.XXXofHarvardUniv.,

andYYofYaleUniv.notbeconsideredasreviewers.Withthanksforyourconsideration,Iam

Sincerelyyours,

case2

DearEditor,

Wewouldliketosubmittheenclosedmanuscriptentitledentitledproteinfrequeninfrequenin

beconsideredforpublicationinNeuron.

Webelievethattwoaspectsofthismanuscriptwillmakeitinterestingtogeneralreadersof

Neuron.First,wereportthatGDNFhasalong-termregulatoryeffectonneurotransmitterrelease

attheneuromuscularsynapses.Thisprovidesthefirstphysiologicalevidenceforaroleofthisnew

familyofneurotrophicfactorsinfunctionalsynaptictransmission.Second,weshowthatthe

GDNFeffectismedi

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