北太平洋外科协会自分泌运动因子受体表达对结直肠癌淋巴结转移预后意义1591-s2 main.pdfVIP

TheAmericanJournalofSurgery(2015)209,884-889

NorthPacificSurgicalAssociation

Prognosticsignificanceofautocrinemotility

factorreceptorexpressionbycolorectalcancer

andlymphnodemetastases

abc

YasminHalwani,M.D.,LilianaD.Kojic,Ph.D.,SimonK.Chan,M.Sc.,

TerryP.Phang,M.D.,M.Sc.ad

,HamidMasoudi,M.D.,

StevenJ.M.Jones,Ph.D.cb

,IvanR.Nabi,Ph.D.,

SamM.Wiseman,M.D.a,*

aDepartmentofSurgery,St.Paul’sHospital,bDepartmentofCellularandPhysiologicalSciences,

cDepartmentofMedicalGenetics,anddDepartmentofPathologyandLaboratoryMedicine,St.Paul’s

Hospital,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada

KEYWORDS:

Coloncancer;BACKGROUND:Autocrinemotilityfactorreceptor(AMFR)hasbeenlinkedtometastasisand

Rectalcancer;tumorigenicity.TheaimofthisstudywastoevaluateexpressionandprognosticsignificanceofAMFR

Tissuemicroarray;incolorectalcarcinoma.

AutocrinemotilityMETHODS:AMFRexpressionwasevaluatedin127coloncancerspecimens,131rectalcancerspec-

factorreceptorimens,and47colonicand25rectalcorrespondinglymphnodemetastases.Clinicopathologicalcorre-

latesofprognosticsignificancewereestablishedbyunivariateandmultivariateanalysis.Spearman’s

correlationdeterminedtheassociationofexpressionbetweencancersandtheirmetastases.

RESULTS:AMFRwasover-expressedby22%ofcoloncanc