缬沙坦联合卡维地洛治疗慢性心力衰竭的效果及对血浆脑钠肽表达水平的影响.docxVIP

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缬沙坦联合卡维地洛治疗慢性心力衰竭的效果及对血浆脑钠肽表达水平的影响

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【摘要】目的：探讨缬沙坦联合卡维地络治疗对慢性心力衰竭的疗效及对BNP表达影响。方法：选择收治慢性心力衰竭患者80例，所有患者均于2017年7月至2019年6月在我院接受治疗，随机分为实验组（n=40）和常规组（n=40）。常规组应用缬沙坦治疗，实验组在此基础上应用卡维地洛治疗，观察并比较两组BNP表达水平、心功能。结果：治疗前两组EDV、LVEDD、LVEF对比差异无统计学意义（P0.05）。治疗后实验组EDV、LVEDD显著低于常规组，LVEF显著高于常规组（P0.05）。治疗前两组BNP水平对比差异无统计学意义（P0.05）。治疗后实验组BNP水平显著低于常规组（P0.05）。结论：慢性心力衰竭治疗中缬沙坦联合卡维地洛疗效显著，可有效改善患者心功能，降低BNP水平，值得进行广泛推广。

【关键词】卡维地洛；缬沙坦；心力衰竭；心功能；血浆脑钠肽

[Abstract]objective:toinvestigatetheeffectofvalsartancombinedwithcarvedilolonchronicheartfailureanditseffectonBNPexpression.Methods:80patientswithchronicheartfailurewereselected,andallpatientsweretreatedinourhospitalfromJuly2017toJune2019,randomlypidedintoexperimentalgroup(n=40)andconventionalgroup(n=40).Theconventionalgroupwastreatedwithvalsartan,whiletheexperimentalgroupwastreatedwithcarvedilol.TheexpressionlevelandcardiacfunctionofBNPinthetwogroupswereobservedandcompared.Results:therewasnostatisticallysignificantdifferenceinEDV,LVEDDandLVEFbetweenthetwogroupsbeforetreatment(P0.05).Aftertreatment,EDVandLVEDDintheexperimentalgroupweresignificantlylowerthanthoseintheconventionalgroup,andLVEFwassignificantlyhigherthanthatintheconventionalgroup(P0.05).TherewasnosignificantdifferenceinBNPlevelsbetweenthetwogroupsbeforetreatment(P0.05).Aftertreatment,thelevelofBNPintheexperimentalgroupwassignificantlylowerthanthatintheconventionalgroup(P0.05).Conclusion:valsartancombinedwithcarvediloliseffectiveinthetreatmentofchronicheartfailure,whichcaneffectivelyimprovethecardiacfunctionofpatientsandreducethelevelofBNP,andisworthyofextensivepromotion.

【Keywords】carvedilol;Valsartan;Heartfailure;Cardiacfunction;Plasmabrainnatriureticpeptide

慢性心力衰竭是心脏病发展至终末期的常见类型，为复杂的临床症候群，会导致心脏射血能力下降和心室充盈减少。临床研究[

1]显示，该疾病发病率随着年龄的增长而上升，病死率超