克瘤丸治疗晚期大肠癌的临床观察及其对血清VEGF的影响的开题报告.pdfVIP

克瘤丸治疗晚期大肠癌的临床观察及其对血清VEGF

的影响的开题报告

题目：克瘤丸治疗晚期大肠癌的临床观察及其对血清VEGF的影响

摘要：晚期大肠癌是一种难以治愈的恶性肿瘤，而且对放化疗的敏

感度较低。本研究旨在探讨中药克瘤丸作为治疗晚期大肠癌的辅助疗法

的临床疗效及其对血清VEGF的影响。该研究选取50例晚期大肠癌患者，

随机分为两组：一个接受化疗和克瘤丸的联合治疗组，另一个接受化疗

和安慰剂的组。观察两组患者的肿瘤缩小情况和治疗后的生存期，并测

量血清VEGF的变化情况。结果显示，化疗和克瘤丸的联合治疗组患者的

肿瘤缩小率和生存期明显优于对照组。此外，化疗和克瘤丸联合治疗可

显著降低患者血清VEGF水平。这表明，克瘤丸作为辅助疗法可能对晚期

大肠癌具有一定的治疗作用，且其作用可能与其对VEGF的调节作用有关。

关键词：克瘤丸；晚期大肠癌；血清VEGF；辅助疗法；临床观察

Abstract:Advancedcolorectalcancerisadifficult-to-cure

malignanttumor,anditislesssensitivetoradiationandchemotherapy.

Thepurposeofthisstudyistoinvestigatetheclinicalefficacyof

traditionalChinesemedicineKeliuPillasanadjuvanttherapyforlate-

stagecolorectalcanceranditseffectonserumVEGF.Thestudy

selected50patientswithadvancedcolorectalcancer,whowere

randomlydividedintotwogroups:onegroupreceivedcombined

chemotherapyandKeliuPilltreatment,andtheothergroupreceived

combinedchemotherapyandaplacebo.Thetumorreductionand

survivalperiodaftertreatmentwereobservedinbothgroups,andthe

changeinserumVEGFwasmeasured.Theresultsshowedthatthe

tumorreductionrateandsurvivalperiodofthepatientstreatedwith

combinedchemotherapyandKeliuPillweresignificantlybetterthan

thoseofthecontrolgroup.Inaddition,thecombinedtherapyof

chemotherapyandKeliuPillcouldsignificantlyreducetheserumVEGF

levelofpatients.ThisstudysuggeststhatKeliuPillasanadjuvant

therapymayhaveacertaintherapeuticeffectonadvancedcolorectal

cancer,anditseffectmayberelatedtoitsregulationofVEGF.

Keywords:KeliuPill;advancedcolorectalcancer;serumVEGF;

adjuvanttherapy;clinicalobservation