CAR-T肿瘤免疫治疗[精品课件].pptxVIP

Chimericantigenreceptor(CAR)T-cellImmunotherapy嵌合抗原受体T细胞免疫疗法Presenter：xxxDate：

1.IntroductionofCAR-Ttherapy2.ClinicalapplicationsofCAR-Ttherapy3.ResistancetoCAR-Ttherapy4.ToxicitiesofCAR-Ttherapy目录

Part1.IntroductionHallmarksofCancerCAR-Ttherapy

HanahanD,etal.Cell2011,144(5):646-674.PavlovaNN,etal.CellMetab2016,23(1):27-47.HallmarksofCancerSixacquiredbiologicalcapabilitiesduringthedevelopmentofhumantumorsEmerginghallmarks(e.g.metabolismhallmark)

ImmunologicaltolerancetocancerFeinsS,etal.AmJHematol2019,94(S1):S3-s9.Breakingtole