Avutometinib-potassium-Ro-5126766-potassium-生命科学试剂-MCE.pdf

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Avutometinibpotassium

Cat.No.:HY-18652A

CASNo.:946128-90-1

Synonyms:Ro5126766potassium;CH5126766potassium

分⼦式:C₂₁H₁₈FKN₅O₅S

分⼦量:510.56

作⽤靶点:Raf;MEK

作⽤通路:MAPK/ERKPathway

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Avutometinib(potassium)是⼀种RAF/MEK钳⼦，能有效抑制RAF/MEK激酶活性，诱导RAF-MEK负复合体

，阻⽌ARAF，BRAF和CRAF对MEK的磷酸化。Avutometinib(potassium)在携带KRAS突变的肿瘤细胞系

(包括PDAC细胞系)中显⽰出抗增殖能⼒。在KRAS/p53胰腺癌⼩⿏模型中，Avutometinib(potassium)诱导

肿瘤抑制并提⾼⽣存率。Avutometinib(potassium)有望⽤于低级别浆液性卵巢癌(LGSOC)，卵巢癌和胰腺导

管腺癌(PDAC)的研究[1][2]。

客户使⽤本产品发表的科研⽂献

•ClinSci(Lond).2019Apr16;133(8):919-932.

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REFERENCES

[1].McNamaraB,etal.PreclinicalefficacyofRAF/MEKclampavutometinibincombinationwithFAKinhibitioninlowgradeserousovarian

cancer.GynecolOncol.2024Apr;183:133-140.

[2].ComaS,etal.AbstractA091:TheRAF/MEKclampavutometinibasthebackbo