新生儿英用药课件.ppt

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NeonatalMedicine

--IntroductionXiaopingLuo,MDProfessorandChairmanDepartmentofPediatrics,TongjiHospitalDirector,CenterfortheDiagnosisofGeneticMetabolicDiseasesTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyAdjunctProfessorDepartmentofPaediatricsFacultyofMedicineUniversityofTorontoToronto,Canada新生儿英用药

HistoricalPerspectivesEarlyHistoryofCareofInfants(1900~-smallinfantswerenotexpectedtolive-temperature:hot-waterbottles,heatedcribs-feeding:tubefeeding,dilutedcowmilk-separatedfacilities,isolation,washinghands-hyalinemembranediseases---respiratorydistresssyndrome-1940s,modernizedincubator,moreoxygen-1940s,retrolentalfibroplasia-1945,《ThePhysiologyoftheNewbornInfant》--C.Smith新生儿英用药

HistoricalPerspectivesRapidAdvancesinNeonatalCare(1955~1970)-1959,surfactantdeficiency,AveryME,MeadJ.AmJDisChild-1960,《DiseaseoftheNewborn》-Neonatology-A.Schaffer-culture,bloodcounts,urinalyses,radiographs,biopsies-milkformulas,breastmilkbank-ivglucosebicarbonate-bloodgasanalysis-improvedincubators-earlyattemptsofmechanicalventilation新生儿英用药

HistoricalPerspectivesEmergenceofneonatalIntensiveCare(1971~1989)-1971,continuouspositiveairwaypressure(CPAP)--Gregory-neonatalintensivecareunit(NICU)-designatedbylevelaccordingtotheintensityofserviceI:normalbirthingandNBcare,II:commonobstetriccomplicationsintermediateNBcareIII:highriskmaternalcareandNICU-transferringofhighriskinfantsormothers-highriskandlongtermoutcome-1980s,extracorporealmembraneoxygenation(ECMO)新生儿英用药

HistoricalPerspectivesExpansionofClinicalTrialstoAssessTherapy:theSurfactantEra(1980~1996)-1970s~1990s,glucocorticoidsto

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