FTI-277-TFA-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

FTI-277TFA

Cat.No.:HY-110038

CASNo.:1217447-06-7

分⼦式:C₂₄H₃₀F₃N₃O₅S₂

分⼦量:561.64

作⽤靶点:FarnesylTransferase;Apoptosis;Ras

作⽤通路:MetabolicEnzyme/Protease;Apoptosis;GPCR/GProtein;

MAPK/ERKPathway

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性FTI-277TFA是法尼基转移酶FTase抑制剂，⾼效RasCAAX肽模拟物，可抑制H-Ras和K-Ras信号转导。FTI-

277TFA可抑制hepatitisdeltavirus(HDV)感染。

客户使⽤本产品发表的科研⽂献

•FishShellfishImmunol.2019Apr3;89:281-289.

•Oncotarget.2017Nov22;8(65):109135-109150.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].Cohen-JonathanE,etal.ThefarnesyltransferaseinhibitorFTI-277suppressesthe24-kDaFGF2-inducedradioresistanceinHeLacells

expressingwild-typeRAS.RadiatRes.1999Oct;152(4):404-11.

[2].NakazawaH,etal.Roleofproteinfarnesylationinburn-inducedmetabolicderangementsandinsulinresistanceinmouseskeletal

muscle.PLoSOne.2015Jan16;10(1):e0116633.

[3].