中药抗肿瘤药的研究进展dxy.pptVIP

中药抗肿瘤药的研究进展ReviewoftheeffectsofTCMoncarcinomacells郧阳医学院附属人民医院药学部汪选斌中药抗肿瘤药的研究进展中药抗肿瘤的作用机制中药抗肿瘤的临床应用思考与展望中药抗肿瘤的作用机制诱导细胞分化诱导细胞凋亡干扰核酸的合成抑制微管蛋白的活性阻滞细胞周期逆转多药耐药其它诱导细胞分化药物肿瘤细胞靶点淫羊藿苷（Icariin）HL-60可能与升高cAMP/cGMP比值有关苦参碱(Matrine)SMMC-7721、K562、HL60诱导分化当归多糖（AngelicaPolysaccharide）小鼠移植性肿瘤EC、Hep、S180、Lewis、B16；K562增值分化DifferentiationofK-562cellsinducedbyMatrine.ANormalK-562cellswereirregularinshape,mostlyround,uneveninsize,scarcecytoplasm,andhadlargeandirregularnucleiandseveralclearnucleoli.BMatrine-induced(0.1mg/m)changesinthemorphologyofK-562cellswerecharacterizedbydecreasedcellsize,smallernucleuscytoplasmratio,condensedchromatinanddisappearednucleoli,andresembledpolychromaticnormoblastsandorthochromaticnormoblasts.诱导细胞凋亡诱导细胞凋亡药物肿瘤细胞靶点蟾蜍灵(Bufalin)K562、MGc-803诱导凋亡莪术提取物榄香烯(Elemene)HL－60诱导凋亡丹参酮(Tanshinone)HL－60;K562Bcl-2低表达As2O3（ArsenicTrioxide）Colo-16；HepG2;R-HepG2Bcl-2低表达；抑制核酸的合成药物肿瘤细胞靶点蟾酥（VenenumBufonis）BTT739小鼠膀胱癌抑制DNA合成抑制微管蛋白的活性药物肿瘤细胞靶点长春新碱(vincristine)BTT739小鼠膀胱癌使纺锤体微管蛋白变性；多西紫杉醇(docetaxel)HL－60促进微管聚合、抑制微管解聚、变性阻滞细胞周期药物肿瘤细胞靶点扶正抑瘤汤（黄芪、当归、莪术、墓回头）BTT739小鼠膀胱癌S期土贝母苷HL－60G2/M加味四君子汤HL－60;K562G0/G1逆转多药耐药Drugresistanceisaseriesofprocess?MDRDefectsinapoptoticsignallingglutathioneTopoisomeraseplasmamembraneproteinsoftheATP-bindingcassette(ABC)superfamily逆转多药耐药柴胡逆转肝细胞癌多药耐药作用与相关机制的研究Fig.1ExpressionofP-gpinBel-7402cells(A)Bel-7402cells.S-Pmethod×400;(B)Bel-7402cellsafterBCDCTreatmentfor3d.S-Pmethod×400.Fig.2ThelevelofMDR1,GSTπandTopoⅡαgenetranscriptinBel-7402andBel-7402cellstreatedby390g/mLBCDC(lane1,2,3,4,5,6respectively)川芎嗪(Ligustrazine，TMP)川芎嗪联合维拉帕米对人胃癌耐药细胞SGC7901/ADM多药耐药的逆转作用研究HepG2R-HepG2doxorubicin/1wdoxorubicin/4wvincristine/1wvincristine/4wAs2O3/1wAs2O3/4wR-HepG2ThisresultindicatedthatAs2O3isnotthesubstrateofP-glycoproteinandthu