急性胃肠炎病毒.ppt

GastrointestinalViruses

ViralGastroenteritisItisthoughtthatvirusesareresponsibleforupto3/4ofallinfectivediarrhoeas.1Viralgastroenteritisisthesecondmostmonviralillnessafterupperrespiratorytractinfection.2Indevelopingcountries,viralgastroenteritisisamajorkillerofinfantswhoareundernourished.Rotavirusesareresponsibleforhalfamilliondeathsayear.3Manydifferenttypesofvirusesarefoundinthegutbutonlysomeareassociatedwithgastroenteritis.4

AssociatedwithgastroenteritisRotavirusesAdenoviruses4041Caliciviruses嵌杯病毒NorwalklikevirusesorSRSV(SmallRoundStructuredViruses)AstrovirusesSRV(SmallRoundViruses)CoronavirusesToroviruses

Foundinthegut,notnormallyassociatedwithgastroenteritisPolioCoxsackieACoxsackieBEchoEnteroviruses68-71HepatitisAHepatitisEAdenoviruses1-39Reoviruses

FoundinthegutasopportunisticinfectionCMVHSVVZVHIV

GastrointestinalVirusesVirusGenomeTypicaldiseaseincubationDurationRotaviruses:GroupA,B,Cds-segmentedRNAMajorcauseofdiarrheainchildren1-3days24-56h5-8days3-7daysCalicivirusesNorwalkagentsssRNAInfectsadultsandchildrenEpidemicviralgastroenteritis1-3days18-24h1-3days12-48hEAd40,41LineardsRNAdiarrheainchildren7-8days8-12dAstrovirus+ssRNAInfectsmainlychildrenandelderly1-4days1-4d

GastrointestinalVirusesInfants:RotavirusA;Adenovirus40,41;CoxsackieA24virusInfants,children,andadultsNorwalkvirus;Calicivirus嵌杯病毒;astrovirus;RotavirusB;Reovirus.

HumanRotavirus

ImportantCharacteristicsnmround,doubleshelled,enclosingagenomeof11segmentsofdoublestrandedRNA.”

GroupsofRotavirusesGroupAsubtypes1,2,3,4(mainhumanpathogens)

(Further7subtypes)alsoinfectanimals(monkey,calf,mouse)GroupBInfectspigsandrats

FoundtocauseextensiveoutbreaksinChinainpastdecadeGroupCInfectsPigs(OccasionallyMan)GroupDInfectsbirdsGroupEInfectspigs

Essentiallyaningestiondisease(faeca