Enzastaurin-di-hydrochloride-LY317615-dihydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Enzastaurindi(hydrochloride)

Cat.No.:HY-10539

CASNo.:365253-37-8

Synonyms:LY317615dihydrochloride

分⼦式:C₃₂H₃₁Cl₂N₅O₂

分⼦量:588.53

作⽤靶点:PKC;Autophagy;Apoptosis

作⽤通路:Epigenetics;TGF-beta/Smad;Autophagy;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Enzastaurin(LY317615)dihydrochloride是⼀种有效的PKCβ抑制剂，IC50值为6nM。Enzastaurin

dihydrochloride对PKCβ选择性是PKCα，PKCγ和PKCε的6-20倍。

客户使⽤本产品发表的科研⽂献

•Cell.2023Jun22;186(13):2929-2949.e20.

•SciTranslMed.2018Jul18;10(450).pii:eaaq1093.

•NatCommun.2020Apr14;11(1):1792.

•Autophagy.2024Jun24.

•Oncogene.2022Jan27.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].RovedoMA,etal.Inhibitionofglycogensynthasekinase-3increasesthecytotoxicityofenzastaurin.JInvestDermatol,2011,131(7),

1442-1449.

[2].PodarK,etal.TargetingPKCinmultiplemyeloma:invitroandinvivoeffectsofthenovel,orallyavailablesmall-moleculeinhibitor

enzastaurin(LY317615.HCl).Blood,2007,109(4),1669-1677.

[3].GraffJR,etal.TheproteinkinaseCbeta-selectiveinhibitor,Enzastaurin(LY317615.HCl),suppressessignalingthroughtheAKT

pathway,inducesapoptosis,andsuppressesgrowthofhumancolonca