本科病理学肿瘤.pptVIP

癌的组织学特点－形成癌巢nestpattern男，65岁。左颞部皮肤肿物2年，缓慢增大，表面溃疡形成.二、间叶组织肿瘤**lipoma脂肪瘤angioma,hemangioma血管瘤leiomyoma平滑肌瘤间叶组织良性肿瘤Lipoma脂肪瘤最常见的结缔组织肿瘤；有包膜，色黄，常位于皮下；镜下由分化成熟的脂肪细胞构成；临床一般无症状.Well-circumscribed界限清楚Closelyresembletomatureadipocytes分化成熟Lipoma脂肪瘤第八节良性肿瘤与恶性肿瘤的区别P91良性肿瘤(p92表）welldifferentiated分化好slowrateofgrowth生长慢fewmitoses,nonecrosisnoinvasion无浸润expansilegrowth,smoothborder, encapsulatednometastases无转移子宫平滑肌瘤**Locallesions:bleeding,necrosis,pain,infection,destructionofstructuresandfunctionsofinvolvedtissuesandorgansMalignanttumorsPoor-differentiated分化差Growrapidly生长快Invasionandmetastasis侵袭和转移**Comparisonbetweenabenigntumorofthemyometrium(leiomyoma)andamalignanttumorofthesameorigin(leiomyosarcoma).病例观察与诊断练习男，45岁。腹泻、大便带血3个月。结肠绒毛状腺瘤**结肠绒毛状腺瘤恶变，结肠腺癌鉴别要点**组织学指征：异型性，核分裂生物学行为：生长，转移，复发恶性特征:分化不好生长快，浸润转移加破坏12Bewaretraps!**Borderlinetumors交界性肿瘤01Malignantchange恶变02malignantbenignborderline(一)上皮组织良性肿瘤**papilloma:乳头状瘤起源：被覆上皮部位：体表、粘膜表面生长：外生性结构：实质包间质结局：某些部位易恶变第九节常见肿瘤举例0102Squamouscellpapillomatransitionalcellpapilloma乳头状瘤BenignEpithelialTumorsadenoma腺瘤由腺体、导管或分泌上皮发生Sites:甲状腺、卵巢、乳腺…ExamplesofCommontumors常见类型：tubularadenoma管状腺瘤cystadenoma囊腺瘤fibroadenoma纤维腺瘤pleomorphicadenoma多形性腺瘤polypousadenoma息肉状腺瘤BenignEpithelialTumorsSerouscystadenoma,ovaryBenignEpithelialTumors卵巢浆液性囊腺瘤BenignEpithelialTumorsSerouscystadenoma,ovary乳腺纤维腺瘤,fibroadenoma,breastBenignEpithelialTumors涎腺多形性腺瘤,pleomorphicadenoma,salivaryglandBenignEpithelialTumorsBenignEpithelialTumors结肠息肉状腺瘤,polypousadenoma,colonBenignEpithelialTumors(二)上皮组织恶性肿瘤**Commonfeatures：多见于40岁以上以浸润性生长方式为主灰白色肿块，较干燥镜下癌巢结构淋巴道扩散为主Carcinoma,癌1.SquamousCellCarcinoma鳞状细胞癌皮肤，食道，宫颈，鼻咽，肺等SquamousCellCarcinoma角化珠01SquamousCellCarcinoma02细胞间桥SquamousCellCarcinomaSquamousCellCarcinomaTub