Encequidar-hydrochloride-HM30181-hydrochloride-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Encequidarhydrochloride

Cat.No.:HY-13646B

CASNo.:849675-88-3

Synonyms:HM30181hydrochloride;HM30181Ahydrochloride

分⼦式:C₃₈H₃₇ClN₆O₇

分⼦量:725.19

作⽤靶点:P-glycoprotein

作⽤通路:MembraneTransporter/IonChannel

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Encequidarhydrochloride(HM30181hydrochloride)是⼀种⼝服P-glycoprotein(P-gp)抑制剂，具有增强P-

gp底物药物的⼝服⽣物利⽤度活性。Encequidar在多种MDR1抑制剂中显⽰出最⾼的效⼒，IC50=0.63nM。

Encequidar有效阻⽌了在MDCK单层细胞中的紫杉醇的跨上⽪运输，IC50=35.4nM。

客户使⽤本产品发表的科研⽂献

•NatCommun.2021Jan12;12(1):312.

•EMBOJ.2024Aug19.

•HepatolCommun.2024May2;8(5):e0437.

•CritRevAnalChem.2021Mar10;1-15.

Seemorecustomervalidationsonwww.MedChemE

REFERENCES

[1].BauerF,etal.InteractionofHM30181withP-glycoproteinatthemurineblood-brainbarrierassessedwithpositronemission

tomography.EurJPharmacol.2012Dec5;696(1-3):18-27.

[2].KimTE,etal.EffectsofHM30181,aP-glycoproteininhibitor,onthep