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NumericalAbnormalityBefoundmorecommonlythanEuploid(整倍体)ACB亚二倍体:lessthanthenormal2nnumberofchromosomes超二倍体:morethanthenormal2nnumberofchromosomes非整倍体NumericalAbnormality非整倍体单体型:isthepresenceofonlyonecopyofanychromosomeLossofautosomesisnottoleratedTurnersyndrome:45,X亚二倍体BefoundmorecommonlythanMonosomyTrisomyofsexchromosomeismorecommonly超二倍体三体型:isthepresenceofonlythreecopyofanychromosomeNumericalAbnormality非整倍体NumericalAbnormalityMeiotic(减数分裂)non-disjunction单击此处添加小标题Mitotic(有丝分裂)non-disjunction单击此处添加小标题Chromosomenon-disjunction单击此处添加小标题MechanismofAneuploid(非整倍体)单击此处添加小标题Meiosisinanimals.MeioticNon-DisjunctionMeioticnon-disjunctionarisesfromfailureofpairedhomologouschromosomesorsisterchromatidtodisjoinatmeioticanaphase.MeioticNon-Disjunction2NNN+1N-12N+12N+12N-12N-1N+1N+1N-1N-12N2N2N+12N-12NNNNNN-1N+1MeioticNon-DisjunctionPrimarynon-disjunction单击此处添加小标题Primarynon-disjunctionisthefailureofchromosomesorsisterchromatidtoseparateinmeiosis.Thegametethushastwocopiesofachromosome.Fertilizationaddsanothercopytogiveatotalof3copies.单击此处添加小标题Secondarynon-disjunction单击此处添加小标题Trisomyoffspringarisefromsegregationatmeiosisofanalready-trisomyparent.单击此处添加小标题MeioticNon-Disjunction2N+1N2N2N2N+12N+1NN+1NNN+1N+1NumericalAbnormalityMitoticnon-disjunction添加标题MechanismofAneuploid添加标题Meioticnon-disjunction添加标题Chromosomenon-disjunction添加标题01020304Mitosisinanimalcells.MitoticNon-DisjunctionMitoticnon-disjunctionarisesfromfailureofsisterchromatidstodisjoinatmitoticanaphase.2N2N2N2N2N2N-12N+12N2N-12N+147/45Mosaic46/47/45MosaicNumericalAbnormality添加标题Meioticnon-disjunction添加标题Mitoticnon-disjunction添加标题Chromosomeloss添加标题MechanismofAneuploid添加标题Chromosomenon-disjunctionChromosomeLoss01添加标题Thecausalitywhereach
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