高血压与降压治疗策略中国高血压防治指南解读.pptVIP

01040203在中国大陆的降压治疗临床试验STONE↓57%↓41% CNIT↓50%↓44%Syst-China↓38%↓37%FEVER↓28%↓28%StrokeCVD1086420-2-405101530AbsoluteriskofCHDevent(per1000patientsoffollow-up)CHDeventssaved(per1000patient-yearsoftreatment)STOP-1EUROPAPROGESSTESTPATSCoopeWarrenderSyst-EurSyst-ChinaSHEPEWPHEDutchTIAMRC-1HOPEIDNTSCOPEHDFP2040ANBP-1DIABHYCARMRC-EQUIETPEACEPART2RENAAL2535心血管危险程度与降压治疗绝对获益CHDEvents心血管危险程度与降压治疗绝对获益STROKEPROGESS14121086420010203040506070Absoluteriskofstroke(per1000patientsoffollow-up)Strokessaved(per1000patient-yearsoftreatment)STOP-1PATSHSCSGSTONECoopeWarrenderSyst-EURSyst-ChinaSHEPEWPHEMRC-EMRC-1HDFP0.51.02.0RelativeRiskRR(95%CI)BPDifference

(mmHg)Favors

FirstListedFavors

SecondListedMajorCVeventsCVmortalityTotalmortality1.02(0.98,1.07)2/0ACEIvsD/BB1.03(0.95,1.11)2/0ACEIvsD/BB1.00(0.95,1.05)2/0ACEIvsD/BB1.04(0.99,1.08)1/0CAvsD/BB1.05(0.97,1.13)1/0CAvsD/BB0.99(0.95,1.04)1/0CAvsD/BB0.97(0.92,1.03)1/1ACEIvsCA1.03(0.94,1.13)1/1ACEIvsCA1.04(0.98,1.10)1/1ACEIvsCABloodPressureLoweringTreatmentTrialists’Collaboration.Lancet.2003;362:1527-1535.BP-LoweringTreatmentTrialists

ComparisonsofDifferentActiveTreatmentsBPLTT:STROKE

Comparisonsofdifferentactivetreatments

2003RR(95%CI)FavoursfirstlistedFavourssecondlisted0.51.02.0RelativeRiskBPdifference(mmHg)1.09(1.00,1.18)ACEIvs.D/BB0.93(0.86,1.01)CAvs.D/BB1.12(1.01,1.25)ACEIvs.CA2/01/01/10.50.711.42SpecifiedDrugbetter0.50.711.42PlacebobetterSpecifiedDrugbetterPlacebobetter Coronaryheartdiseaseevents Stroke Noof Noof Relativerisk relativerisk Noof Noof Relativerisk Relativerisk trials events (95%CI) (95%CI) trials events (95%CI) (95%CI)Thiazide