Azacyclonol-hydrochloride-γ-pipradol-hydrochloride-生命科学试剂-MCE.pdf

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Azacyclonolhydrochloride

Cat.No.:HY-B0530A

CASNo.:1798-50-1

Synonyms:γ-pipradolhydrochloride

分⼦式:C₁₈H₂₂ClNO

分⼦量:303.83

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Azacyclonol(γ-pipradol)hydrochloride是⼀种具有良好抗癌活性的化合物，可有效抑制A549⼈肺癌细胞中

NOX衍⽣的ROS。Azacyclonolhydrochloride对雄激素抵抗性癌细胞系（特别是DU145和PC-3）表现出增

强的增殖抑制作⽤。Azacyclonolhydrochloride在DU145异种移植绒⽑尿囊膜肿瘤模型中表现出抗肿瘤活性

。Azacyclonolhydrochloride还可作为M3毒蕈碱⼄酰胆碱受体的配体，该受体在ARPC中过度表达。

Azacyclonolhydrochloride可有效阻断DU145细胞中卡巴胆碱诱导的增殖和NOX活性。Azacyclonol

hydrochloride还可⽤于抑制慢性精神分裂症。

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REFERENCES

[1].Synthesisandanticancerevaluationof6-azacyclonol-2,4,6-trimethylpyridin-3-olderivatives:M3muscarinicacetylcholinereceptor-

mediatedanticanceractivityofacyclohexylderivativeinandrogen-refractoryprostatecancer

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