Mimopezil-ZT-1-生命科学试剂-MCE.pdf

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Mimopezil

Cat.No.:HY-14795

CASNo.:180694-97-7

Synonyms:ZT-1

分⼦式:C₂₃H₂₃ClN₂O₃

分⼦量:410.89

作⽤靶点:Cholinesterase(ChE)

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Mimopezil(ZT-1)是⼀种胆碱酯酶抑制剂，在⽔或⽔溶性有机溶剂中会迅速降解为活性代谢物HuperzineA

(HY-17388)。Mimopezil⼝服后吸收迅速但⽣物利⽤度低(0.37%，⼤⿏)，但代谢后转化为Huperzine

A，HuperzineA在⾎液中积累并具有较强的活性。静脉给药后Mimopezil⾎药浓度较⾼，同样迅速代谢为

HuperzineA[1]。

REFERENCES

[1].LiC,etal.AsensitivemethodforthedeterminationofthenovelcholinesteraseinhibitorZT-1anditsactivemetabolitehuperzineAinrat

bloodusingliquidchromatography/tandemmassspectrometry.RapidCommunMassSpectrom.2004;18(6):651-6.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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