D-Dopa-3-Hydroxy-D-tyrosine-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

D-Dopa

Cat.No.:HY-W096171

CASNo.:5796-17-8

Synonyms:3-Hydroxy-D-tyrosine

分⼦式:C₉H₁₁NO₄

分⼦量:197.19

作⽤靶点:Carboxypeptidase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:4°C,protectfromlight,storedundernitrogen

*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light,storedundernitrogen)

BIOLOGICALACTIVITY

⽣物活性D-Dopa⼀种⾮竞争性变构抑制剂，可抑制⾕氨酸羧肽酶II(GCPII)，IC50为200nM。D-Dopa在⼩⿏模型中

表现出良好的药代动⼒学特征和低⾎脑屏障通透性。

IC50TargetIC50:200nM(GCPII)

REFERENCES

[1].GoriSS,etal.,D-DOPAIsaPotent,OrallyBioavailable,AllostericInhibitorofGlutamateCarboxypeptidaseII.Pharmaceutics.2022Sep

23;14(10):2018.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师